i don't understand? you mean try to start game without a dvd? how is this possible. 
no I haven't. 
have downloaded 4 updates on this site, .net framework 3.5 sp1, redist, RGSC 1.88Mb  
update sp3, launchgta4.exe and visual c++ update.   i've followed the  
installation activation as per rockstar site for offline play, do not want to play  
online. 
although there were 2 versions of visual c++ update and one got deleted. only one now at  
5.21Mb.  
i haven't done anything to enable ports, don't know which ones or if it's necessary. 
firewalls/anti-vir/win security settings are disabled when try to run game, 
so it should start? no go