I have an EVGA 8800GTS 320MB superclocked and it now runs great after installing the patch on the following (forced) settings.
Statistics
Average FPS: 43.34
Duration: 37.06 sec
CPU Usage: 89%
System memory usage: 72%
Video memory usage: 100%
Graphics Settings
Video Mode: 1280 x 1024 (60 Hz)
Texture Quality: Medium
Render Quality: Medium
View Distance: 20
Detail Distance: 10
Hardware
Microsoft Windows XP Professional
Service Pack 3
Video Adapter: NVIDIA GeForce 8800 GTS
Video Driver version: 180.84
Audio Adapter: Realtek HD Audio output
IntelĀ® Core2 Duo CPU E6750 @ 2.66GHz
File ID: benchmark.cli
My CPU is overclocked to 3.2 Ghz and i'm currently running 2Gb of memory although this will increase to 4Gb next week. Before the patch the game was unplayable and constantly crashed to desktop, apart from the occasional graphical glitch it is now infinately better. I will report back when I get the extra memory to see if it makes a difference.