You guys are kidding right?
-Gym glitch. You cant work out at the gym, it keeps saying you've worked out enough and you have to come back later. When you come back later, it gives you the same message
-Basketball glitch. Basketballs dissapear and you cant play the basketball mini-game
-girlfriend glitch. Girlfriends arnt home at the time they're suppoed to be home
-peds raise arms glitch. The peds in some interiors raise thier arms up even though you havent fired a gun or locked onto anybody. Casinos and pool games wont work properly then. Even if you exit the interior and come back, theier arms are still up
-wrong sex appeal glitch. When you change haircuts, clothes, etc the sex appeal numbers arnt correct and can somtimes make you have the wrong amount of sex appeal. Once I wore nothing but had the sex appeal as if I was wearing a full tuxedo.
-Madd Dogg glitch. Madd Dogg jumps off the roof the second you get control of CJ, impossible to complete the mission and finish the game.
-Ped wont die glitch. The peds health is black when you lock onto them but theyre not dead. Ive tried shotting them, runing them over, but they just wont die. Only drowining or a stab in the neck with a knife can kill them
-No fire extinguisher glitch. Happends when you start a new game in the options menu.
-Girfriend reward glitch. If you start a new game in the menu and you had Barbera or Katie as a girlfriend in the previous save, you wont lose yoiur weapons in the new save, even though you dont have the girlfriends yet.
These are all of the major glitches I can remember. There are plenty of small glitches like cars getting stuck in walls, etc